Effects of tDCS on spontaneous spike activity in a healthy ambulatory rat model.

ABSTRACT:

Background

The neurophysiological effects of transcranial direct current stimulation (tDCS) are typically described with respect to changes in cortical excitability, defined by using transcranial magnetic stimulation pulses to determine changes in motor evoked potentials. However, how individual cortical neurons change firing patterns under the influence of tDCS is largely unknown. While the relatively weak currents produced in the brain by tDCS may not be adequate to directly depolarize neuronal membranes, ongoing neuronal activity, combined with subthreshold changes in membrane polarization might be sufficient to alter the threshold for neural firing.

Objectives

The purpose of this study was to determine the effects of tDCS on neurophysiological activity in motor cortex of

SUBMITTER: Milighetti S 

PROVIDER: S-EPMC7722157 | biostudies-literature | 2020 Nov - Dec

REPOSITORIES: biostudies-literature