Deep brain stimulation of terminating axons.

ABSTRACT:

Background

Deep brain stimulation (DBS) of the subthalamic region is an established treatment for the motor symptoms of Parkinson's disease. Several types of neural elements reside in the subthalamic region, including subthalamic nucleus (STN) neurons, fibers of passage, and terminating afferents. Recent studies suggest that direct activation of a specific population of subthalamic afferents, known as the hyperdirect pathway, may be responsible for some of the therapeutic effects of subthalamic DBS.

Objective

The goal of this study was to quantify how axon termination affects neural excitability from DBS. We evaluated how adjusting different stimulation parameters influenced the relative excitability of terminating axons (TAs) compared to fibers of passage (FOPs).

Methods

SUBMITTER: Bower KL 

PROVIDER: S-EPMC7722159 | biostudies-literature | 2020 Nov - Dec

REPOSITORIES: biostudies-literature