Antenatal corticosteriods decrease forced vital capacity in infants born fullterm.

ABSTRACT: Antenatal corticosteroids (ACS) administration to pregnant women for threatened preterm labor is standard obstetric care to reduce neonatal respiratory distress syndrome and the associated respiratory morbidity. While ACS stimulates surfactant production in the fetal lung, the effects of ACS upon the subsequent growth and development of the lung are unclear. Follow-up studies outside of the neonatal period have been primarily limited to spirometry, and most subjects evaluated were born prematurely. To our knowledge, no study has assessed both airway and parenchymal function in infants or adults following ACS exposure. We hypothesized that ACS impairs lung growth and performed infant pulmonary function testing, which included spirometry, alveolar volume (V_A ) and lung diffusion (

SUBMITTER: Bandyopadhyay A 

PROVIDER: S-EPMC7722163 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature