Influence of structural and functional brain connectivity on age-related differences in fluid cognition.

ABSTRACT: We used graph theoretical measures to investigate the hypothesis that structural brain connectivity constrains the influence of functional connectivity on the relation between age and fluid cognition. Across 143 healthy, community-dwelling adults 19-79 years of age, we estimated structural network properties from diffusion-weighted imaging and functional network properties from resting-state functional magnetic resonance imaging. We confirmed previous reports of age-related decline in the strength and efficiency of structural networks, as well as in the connectivity strength within and between structural network modules. Functional networks, in contrast, exhibited age-related decline only in system segregation, a measure of the distinctiveness among network modules. Aging was associated wi

SUBMITTER: Madden DJ 

PROVIDER: S-EPMC7722190 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature