Submucosal enteric neurons of the cavine distal colon are sensitive to hypoosmolar stimuli.

ABSTRACT:

Key points

Neurons of the enteric submucous plexus are challenged by osmolar fluctuations during digestion and absorption of nutrients. Central neurons are very sensitive to changes in osmolality but knowledge on that issue related to enteric neurons is sparse. The present study focuses on investigation of osmosensitivity of submucosal neurons including potential molecular mediating mechanisms. Results show that submucosal neurons respond to hypoosmolar stimuli with increased activity which is partially mediated by the transient receptor potential vanilloid 4 channel. We provided important information on osmosensitive properties of enteric neurons. These data are fundamental to better explain the nerve-mediated control of the gastrointestinal functions during physiological and path

SUBMITTER: Kollmann P 

PROVIDER: S-EPMC7722197 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature