Different patterns of functional network reorganization across the variants of primary progressive aphasia: a graph-theoretic analysis.

ABSTRACT: Primary progressive aphasia (PPA) is a neurodegenerative syndrome with three main variants (nonfluent, logopenic, semantic) that are identified primarily based on language deficit profiles and are associated with neurotopographically distinct atrophic patterns. We used a graph-theoretic analytic approach to examine changes in functional network properties measured with resting-state fMRI in all three PPA variants compared with age-matched healthy controls. All three variants showed a more segregated network organization than controls. To better understand the changes underlying the increased segregation, we examined the distribution of functional "hubs". We found that while all variants lost hubs in the left superior frontal and parietal regions, new hubs were recruited in different areas

SUBMITTER: Tao Y 

PROVIDER: S-EPMC7722221 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature