Bone formation around unstable implants is enhanced by a WNT protein therapeutic in a preclinical in vivo model.

ABSTRACT:

Objectives

Our objective was to test the hypothesis that local delivery of a WNT protein therapeutic would support osseointegration of an unstable implant placed into an oversized osteotomy and subjected to functional loading.

Materials and methods

Using a split-mouth design in an ovariectomized (OVX) rat model, 50 titanium implants were placed in oversized osteotomies. Implants were subjected to functional loading. One-half of the implants were treated with a liposomal formulation of WNT3A protein (L-WNT3A); the other half received an identical liposomal formulation containing phosphate-buffered saline (PBS). Finite element modeling estimated peri-implant strains caused by functional loading. Histological, molecular, cellular, and quantitative micro-computed tomographic (µC

SUBMITTER: Coyac BR 

PROVIDER: S-EPMC7722236 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature