Different classes of small RNAs are essential for head regeneration in the planarian Dugesia japonica.

ABSTRACT:

Background

Planarians reliably regenerate all body parts after injury, including a fully functional head and central nervous system. But until now, the expression dynamics and functional role of miRNAs and other small RNAs during the process of head regeneration are not well understood. Furthermore, little is known about the evolutionary conservation of the relevant small RNAs pathways, rendering it difficult to assess whether insights from planarians will apply to other taxa.

Results

In this study, we applied high throughput sequencing to identify miRNAs, tRNA fragments and piRNAs that are dynamically expressed during head regeneration in Dugesia japonica. We further show that knockdown of selected small RNAs, including three novel Dugesia-specific miRNAs, during head regen

SUBMITTER: Cao Z 

PROVIDER: S-EPMC7722302 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature