Effect of bicyclol on blood biomarkers of NAFLD: a systematic review and meta-analysis.

ABSTRACT:

Objective

Non-alcoholic fatty liver disease (NAFLD) is a global epidemic without effective therapeutic agents in the clinic. This meta-analysis aimed to assess the efficacy of the marketed hepatoprotectant bicyclol at improving blood biomarkers in patients with NAFLD.

Design

Electronic databases were searched for randomised controlled trials (RCTs) published up to August 2020 using bicyclol to treat NAFLD. The risk of bias, quality of evidence and publication bias were evaluated. Blood biomarkers, including alanine transaminase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), triglyceride (TG) and total cholesterol (TC), were analysed using Review Manager V.5.3 software. Outcomes with significant heterogeneity (I² ≥75%) were divided into the bicycl

SUBMITTER: Li H 

PROVIDER: S-EPMC7722377 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature