Study protocol: treatment with caffeine of the very preterm infant in the delivery room: a feasibility study.

ABSTRACT:

Introduction

Early treatment with caffeine in the delivery room has been proposed to decrease the need for mechanical ventilation (MV) by limiting episodes of apnoea and improving respiratory mechanics in preterm infants. Thus, the purpose of this feasibility study is to verify the hypothesis that intravenous or enteral administration of caffeine can be performed in the preterm infant in the delivery room.

Methods and analysis

In this multicentre prospective study, infants with 25⁺⁰-29⁺⁶ weeks of gestational age will be enrolled and randomised to receive 20 mg/kg of caffeine citrate intravenously, via the umbilical vein, or enterally, through an orogastric tube, within 10 min of birth. Caffeine plasma level will be measured at 60±15 min after administra

SUBMITTER: Dani C 

PROVIDER: S-EPMC7722383 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature