Multicentre, prospective registry study of amyotrophic lateral sclerosis in mainland China (CHALSR): study protocol.

ABSTRACT:

Introduction

Amyotrophic lateral sclerosis (ALS) is a representative rare disease characterised by progressive, fatal motor neuron degeneration. Due to the unknown aetiology and variability of the phenotypes, there are no accurate reports concerning the epidemiology or clinical characteristics of the disease. The low prevalence, as previously reported, makes it difficult to carry out studies with large samples. The aim of this study was to explore the natural history and clinical features of ALS in mainland China through a multicentre, prospective cohort study. The findings will both offer a better understanding of ALS and also support the development of a model to study other rare diseases.

Methods and analysis

Patients from 88 representative hospitals in different parts of

SUBMITTER: He J 

PROVIDER: S-EPMC7722390 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature