Critical Volume of Human Myocardium Necessary to Maintain Ventricular Fibrillation.

ABSTRACT:

Background

Abnormal QT intervals, long QT or short QT, have been epidemiologically linked with sudden cardiac death because of ventricular fibrillation (VF). Consequently, Food and Drug Administration recommends testing all pharmacological agents for QT toxicity as a risk factor for cardiac toxicity. Such tests assess QT/QTc interval, which represents ventricular depolarization and repolarization. However, the current QT toxicity analysis does not account for the well-known anisotropy in cardiac tissue conductivity. Mines demonstrated in 1913 that cardiac wavelength (λ) determines inducibility of reentrant arrhythmia, where both repolarization time or action potential duration and conduction velocity determine λ=action potential duration×conduction velocity. We aimed to determine t

SUBMITTER: Aras KK 

PROVIDER: S-EPMC7722395 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature