Analysis of ALS-related proteins during herpes simplex virus-2 latent infection.

ABSTRACT:

Background

Genetics have provided hints on potential molecular pathways involved in neurodegenerative diseases (NDD). However, the number of cases caused exclusively by genetic alterations is low, suggesting an important contribution of environmental factors to NDDs. Among these factors, viruses like herpes simplex viruses (HSV-2), capable of establishing lifelong infections within the nervous system (NS), are being proposed to have a role in NDDs. Despite promising data, there is a significant lack of knowledge on this and an urgent need for more research.

Methods

We have set up a mouse model to study HSV latency and its associated neuroinflammation in the spinal cord. The goal of this model was to observe neuroinflammatory changes caused by HSV latent infections, and if th

SUBMITTER: Cabrera JR 

PROVIDER: S-EPMC7722435 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature