Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.

ABSTRACT:

Background

The recent emergence and dissemination of high-level mobile tigecycline resistance Tet(X) challenge the clinical effectiveness of tigecycline, one of the last-resort therapeutic options for complicated infections caused by multidrug-resistant Gram-negative and Gram-positive pathogens. Although tet(X) has been found in various bacterial species, less is known about phylogeographic distribution and phenotypic variance of different genetic variants.

Methods

Herein, we conducted a multiregional whole-genome sequencing study of tet(X)-positive Acinetobacter isolates from human, animal, and their surrounding environmental sources in China. The molecular and enzymatic features of tet(X) variants were characterized by clonal expression, microbial degradation, reverse tran

SUBMITTER: Chen C 

PROVIDER: S-EPMC7722449 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature