Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study.

ABSTRACT:

Objective

To determine the association between levels of low density lipoprotein cholesterol (LDL-C) and all cause mortality, and the concentration of LDL-C associated with the lowest risk of all cause mortality in the general population.

Design

Prospective cohort study.

Setting

Denmark; the Copenhagen General Population Study recruited in 2003-15 with a median follow-up of 9.4 years.

Participants

Individuals randomly selected from the national Danish Civil Registration System.

Main outcome measures

Baseline levels of LDL-C associated with risk of mortality were evaluated on a continuous scale (restricted cubic splines) and by a priori defined centile categories with Cox proportional hazards regression models. Main outcome was all cause mortality. Second

SUBMITTER: Johannesen CDL 

PROVIDER: S-EPMC7722479 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature