Expression profile of circular RNAs in epicardial adipose tissue in heart failure.

ABSTRACT:

Background

Recent studies have reported circular RNA (circRNA) expression profiles in various tissue types; however, circRNA expression profile in human epicardial adipose tissue (EAT) remains undefined. This work aimed to compare circRNA expression patterns in EAT between the heart failure (HF) and non-HF groups.

Methods

RNA-sequencing was carried out to compare circRNA expression patterns in EAT specimens from coronary artery disease cases between the HF and non-HF groups. Quantitative real-time polymerase chain reaction was performed for validation. Comparisons of patient characteristics between the two groups were using t test, Mann-Whitney U test, and Chi-squared test.

Results

A total of 141 circRNAs substantially different between the HF and non-HF groups (P < 0

SUBMITTER: Zheng ML 

PROVIDER: S-EPMC7722589 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature