A three-microRNA panel in serum as novel biomarker for papillary thyroid carcinoma diagnosis.

ABSTRACT:

Background

Accumulating evidence has revealed that circulating microRNAs (miRNAs) can serve as non-invasive biomarkers for cancer diagnosis. This study aimed to identify differentially expressed miRNAs in serum which might become potential biomarkers for non-invasive diagnosis of papillary thyroid carcinoma (PTC).

Methods

The experiment was carried out between 2015 and 2017. In the screening stage, the Exiqon miRNA quantitative real-time polymerase chain reaction (qPCR) panel was applied to select candidate miRNAs. In the following training, testing, and external validation stages, the serum samples of 100 patients and 96 healthy controls (HCs) were analyzed to compare the expression levels of the identified miRNAs. The areas under the receiver operating characteristic curve

SUBMITTER: Zou X 

PROVIDER: S-EPMC7722608 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature