Secondary metabolites of Bacillus subtilis impact the assembly of soil-derived semisynthetic bacterial communities.

ABSTRACT: Secondary metabolites provide Bacillus subtilis with increased competitiveness towards other microorganisms. In particular, nonribosomal peptides (NRPs) have an enormous antimicrobial potential by causing cell lysis, perforation of fungal membranes, enzyme inhibition, or disruption of bacterial protein synthesis. This knowledge was primarily acquired in vitro when B. subtilis was competing with other microbial monocultures. However, our understanding of the true ecological role of these small molecules is limited. In this study, we have established soil-derived semisynthetic mock communities containing 13 main genera and supplemented them with B. subtilis P5_B1 WT, the NRP-deficient strain sfp, or single-NRP mutants incapable of producing surfactin, plipastatin,

SUBMITTER: Kiesewalter HT 

PROVIDER: S-EPMC7722629 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature