Current and potential pharmacological treatment options for insomnia in patients with alcohol use disorder in recovery.

ABSTRACT: Alcohol use disorder (AUD) is characterized by dysfunction in motivational, mood-stress regulation, and sleep systems that interact in complex ways to heighten the risk of relapse during abstinence. Emerging data suggest that excessive and chronic alcohol use disrupts sleep homeostasis and, in abstinence, subjects with AUD are known to experience insomnia that may persist for weeks to years, which we propose to refer to as insomnia associated with alcohol cessation (IAAC). The purpose of this review is to provide an update of pharmacological approaches to therapy including compounds in development, to raise awareness of the prevalence of and unmet need in IAAC and highlight differences in treatment consideration for IAAC as compared to insomnia disorder. We performed a search of select ele

SUBMITTER: Roehrs TA 

PROVIDER: S-EPMC7722668 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature