Vexin is upregulated in cerebral cortical neurons by brain-derived neurotrophic factor.

ABSTRACT:

Aim

Chromosome 8 open reading frame 46 (C8orf46), a human protein-coding gene, has recently been named Vexin. A recent study indicated that Vexin is involved in embryonic neurogenesis. Additionally, some transcriptomic studies detected changes in the mRNA levels of patients with psychiatric and neurological diseases. In our previous study, we sought for target genes of brain-derived neurotrophic factor (BDNF) in cultured rat cortical neurons, finding that BDNF potentially leads to the upregulation of Vexin mRNA. However, its underlying mechanisms are unknown. In the present study, we assessed the regulatory mechanisms of the BDNF-induced gene expression of Vexin in vitro.

Methods

We reanalyzed ChIP-seq data in various human organs provided by the ENCODE project, evaluating a

SUBMITTER: Koshimizu H 

PROVIDER: S-EPMC7722677 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature