Absence of methamphetamine-induced conditioned place preference in weaver mutant mice.

ABSTRACT:

Aims

G protein-activated inwardly rectifying potassium (GIRK) channels are related to rewarding effects of addictive drugs. The GIRK2 subunit is thought to play key roles in the reward system. Weaver mutant mice exhibit abnormal GIRK2 function and different behaviors that are caused by several addictive substances compared with wild-type mice. However, mechanisms of reward-related alterations in weaver mutant mice remain unclear. The present study investigated changes in the rewarding effects of methamphetamine (METH) in weaver mutant mice.

Methods

The rewarding effects of METH (4.0 mg/kg) were investigated using the conditioned place preference (CPP) paradigm. Extracellular dopamine level in the nucleus accumbens (NAc) was measured by in vivo microdialysis. To identify brai

SUBMITTER: Ikekubo Y 

PROVIDER: S-EPMC7722684 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature