Examination of potential novel biochemical factors in relation to prostate cancer incidence and mortality in UK Biobank.

ABSTRACT:

Background

Although prostate cancer is a leading cause of cancer death, its aetiology is not well understood. We aimed to identify novel biochemical factors for prostate cancer incidence and mortality in UK Biobank.

Methods

A range of cardiovascular, bone, joint, diabetes, renal and liver-related biomarkers were measured in baseline blood samples collected from up to 211,754 men at recruitment and in a subsample 5 years later. Participants were followed-up via linkage to health administrative datasets to identify prostate cancer cases. Hazard ratios (HRs) and 95% confidence intervals were calculated using multivariable-adjusted Cox regression corrected for regression dilution bias. Multiple testing was accounted for by using a false discovery rate controlling procedure.

R

SUBMITTER: Perez-Cornago A 

PROVIDER: S-EPMC7722733 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature