EGFR as a stable marker of prostate cancer dissemination to bones.

ABSTRACT:

Background

Prostate cancer (PCa) is among the most commonly diagnosed malignancies in men. Although 5-year survival in patients with localised disease reaches nearly 100%, metastatic disease still remains incurable. Therefore, there is a need for markers indicating metastatic dissemination.

Methods

EGFR overexpression (EGFR^over) was tracked in 1039 primary tumours, circulating tumour cells from 39 d'Amico high-risk patients and metastatic samples from 21 castration-resistant PCa cases. EGFR status was compared to clinical parameters and multiple molecular factors were assessed using immunohistochemistry and gene ontology analysis. The functional aspect of EGFR was evaluated by plating PC-3 cells on soft and rigid matrices.

Results

EGFR^over was fo

SUBMITTER: Nastaly P 

PROVIDER: S-EPMC7722745 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature