Microbe-set enrichment analysis facilitates functional interpretation of microbiome profiling data.

ABSTRACT: The commensal microbiome is known to influence a variety of host phenotypes. Microbiome profiling followed by differential abundance analysis has been established as an effective approach to study the mechanisms of host-microbiome interactions. However, it is challenging to interpret the collective functions of the resultant microbe-sets due to the lack of well-organized functional characterization of commensal microbiome. We developed microbe-set enrichment analysis (MSEA) to enable the functional interpretation of microbe-sets by examining the statistical significance of their overlaps with annotated groups of microbes that share common attributes such as biological function or phylogenetic similarity. We then constructed microbe-set libraries by query PubMed to find microbe-mammalian ge

SUBMITTER: Kou Y 

PROVIDER: S-EPMC7722755 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature