Variations in HIV Risk by Young Women's Age and Partner Age Disparity in Rural South Africa (HPTN 068).

ABSTRACT:

Background

Nearly all population-level research showing positive associations between age-disparate partnerships and HIV acquisition among adolescent girls and young women (AGYW) has classified age disparity as ≥5 or ≥10 years. We describe variations in 1-year risk of HIV infection after exposure to sexual partner(s) of continuous age disparities.

Methods

Longitudinal data from the HPTN 068 randomized trial in South Africa were used to estimate 1-year risk of HIV infection at various age pairings. The parametric g-formula was used to estimate risk at up to 5 annual time points, stratified by maximum partner age difference, maximum partner age, and AGYW age.

Results

AGYW reported an older partner in 86% of 5351 age pairings. The 1-year risk of HIV infection rapidly inc

SUBMITTER: Topazian HM 

PROVIDER: S-EPMC7722780 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature