Long-term safety of prenatal and neonatal exposure to paracetamol: a protocol for a systematic review.

ABSTRACT:

Introduction

A surge in the use of paracetamol in neonates has resulted in growing concerns about its potential long-term adverse events. In this study, we conduct a systematic review of the long-term safety of prenatal and neonatal exposure to paracetamol in newborn infants.

Methods and analysis

We will follow the Joanna Briggs Institute Manual for Evidence Synthesis and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements to conduct and report this review. We will conduct a systematic search of Embase, MEDLINE, Web of Science and Google Scholar for studies with data on long-term adverse events in neonates that were exposed to paracetamol in the prenatal and/or neonatal period. We will not apply language or design limitations. We will use standa

SUBMITTER: Samiee-Zafarghandy S 

PROVIDER: S-EPMC7722805 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature