Trends in acid suppressant drug prescriptions in primary care in the UK: a population-based cross-sectional study.

ABSTRACT:

Objective

To examine proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) prescribing patterns over a 29-year period by quantifying annual prevalence and prescribing intensity over time.

Design

Population-based cross-sectional study.

Setting

More than 700 general practices contributing data to the UK Clinical Practice Research Datalink (CPRD).

Participants

Within a cohort of 14 242 329 patients registered in the CPRD, 3 027 383 patients were prescribed at least one PPI or H2RA from 1 January 1990 to 31 December 2018.

Primary and secondary outcome measures

Annual prescription rates were estimated by dividing the number of patients prescribed a PPI or H2RA by the total CPRD population. Change in prescribing intensity (number of prescripti

SUBMITTER: Abrahami D 

PROVIDER: S-EPMC7722810 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature