Real-world patterns of pegloticase use for treatment of gout: descriptive multidatabase cohort study.

ABSTRACT:

Objective

Pegloticase is used in severe refractory gout or in cases of intolerance to other urate-lowering therapies. We sought to evaluate the patterns of pegloticase use in the USA and the incidence of safety outcomes.

Methods

We conducted a retrospective descriptive study using data from two US commercial insurance claims databases (2010-2018). We identified new initiators of pegloticase with ≥1 gout diagnosis code in the 365-day baseline period prior to pegloticase initiation. We measured the number and duration of pegloticase infusions. We assessed the risk of anaphylaxis or anaphylactoid reactions, cardiovascular events, including myocardial infarction or stroke, and hospitalisation for heart failure (new onset or exacerbations) while undergoing pegloticase therapy.

SUBMITTER: Chen SK 

PROVIDER: S-EPMC7722814 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature