The antiplatelet agent revacept prevents the increase of systemic thromboxane A₂ biosynthesis and neointima hyperplasia.

ABSTRACT: Neointima hyperplasia is a crucial component of restenosis after coronary angioplasty. We have hypothesized that enhanced generation of platelet-derived thromboxane (TX)A₂ in response to vascular damage plays a critical role in neointimal hyperplasia and that antiplatelet agents may mitigate it. In cocultures of human platelets and coronary artery smooth muscle cells (CASMC), we found that platelets induced morphologic changes and enhanced the migration of CASMC. The exposure of platelets to Aspirin [an inhibitor of cyclooxygenase (COX)-1] reduced the generation of TXA₂ and prevented the morphological and functional changes induced by platelets in CASMC. Platelet-derived TXA₂ induced COX-2 and enhanced prostaglandin (PG)E₂ biosynthesis in CASMC,

SUBMITTER: Alberti S 

PROVIDER: S-EPMC7722842 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature