Mesoscopic cortical network reorganization during recovery of optic nerve injury in GCaMP6s mice.

ABSTRACT: As the residual vision following a traumatic optic nerve injury can spontaneously recover over time, we explored the spontaneous plasticity of cortical networks during the early post-optic nerve crush (ONC) phase. Using in vivo wide-field calcium imaging on awake Thy1-GCaMP6s mice, we characterized resting state and evoked cortical activity before, during, and 31 days after ONC. The recovery of monocular visual acuity and depth perception was evaluated in parallel. Cortical responses to an LED flash decreased in the contralateral hemisphere in the primary visual cortex and in the secondary visual areas following the ONC, but was partially rescued between 3 and 5 days post-ONC, remaining stable thereafter. The connectivity between visual and non-visual regions was disorganized after the cru

SUBMITTER: Groleau M 

PROVIDER: S-EPMC7723052 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature