Flavonoids mitigate neurodegeneration in aged Caenorhabditis elegans by mitochondrial uncoupling.

ABSTRACT: Dietary supplementation of flavonoids has been shown to reduce the severity of neurodegenerative disorders such as dementia, Parkinson's disease, and Alzheimer's disease by their antioxidant effects. However, their low bioavailabilityin vivo raises the question of how much their antioxidant capacity actually contributes to the mitigating effects. The physicochemical properties of flavonoids suggest they could function as mitochondrial uncouplers. Moreover, mitochondrial uncoupling alleviated neurodegeneration in Caenorhabditis elegans during aging in previous research. Therefore, we investigated whether various flavonoids (fisetin, quercetin, apigenin, chrysin, catechin, and naringenin) could reduce neuronal defects by mitochondrial uncoupling in C. elegans. Both neuro

SUBMITTER: Cho I 

PROVIDER: S-EPMC7723185 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature