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Induction of labour at 41 weeks or expectant management until 42 weeks: A systematic review and an individual participant data meta-analysis of randomised trials.

ABSTRACT:

SUBMITTER: Alkmark M 

PROVIDER: S-EPMC7723286 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Induction of labour at 41 weeks or expectant management until 42 weeks: A systematic review and an individual participant data meta-analysis of randomised trials.

Alkmark Mårten M   Keulen Judit K J JKJ   Kortekaas Joep C JC   Bergh Christina C   van Dillen Jeroen J   Duijnhoven Ruben G RG   Hagberg Henrik H   Mol Ben Willem BW   Molin Mattias M   van der Post Joris A M JAM   Saltvedt Sissel S   Wikström Anna-Karin AK   Wennerholm Ulla-Britt UB   de Miranda Esteriek E  

PLoS medicine 20201208 12

<h4>Background</h4>The risk of perinatal death and severe neonatal morbidity increases gradually after 41 weeks of pregnancy. Several randomised controlled trials (RCTs) have assessed if induction of labour (IOL) in uncomplicated pregnancies at 41 weeks will improve perinatal outcomes. We performed an individual participant data meta-analysis (IPD-MA) on this subject.<h4>Methods and findings</h4>We searched PubMed, Excerpta Medica dataBASE (Embase), The Cochrane Library, Cumulative Index of Nurs  ...[more]

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