Angiography with optical coherence tomography as a biomarker in multiple sclerosis.

ABSTRACT:

Purpose

To investigate superficial retinal microvascular plexuses detected by optical coherence tomography angiography (OCT-A) in multiple sclerosis (MS) subjects and compare them with healthy controls.

Methods

A total of 92 eyes from 92 patients with relapsing-remitting MS and 149 control eyes were included in this prospective observational study. OCT-A imaging was performed using Triton Swept-Source OCT (Topcon Corporation, Japan). The vessel density (VD) percentage in the superficial retinal plexus and optic disc area (6 x 6 mm grid) was measured and compared between groups.

Results

MS patients showed a significant decrease VD in the superior (p = 0.005), nasal (p = 0.029) and inferior (p = 0.040) parafoveal retina compared with healthy subjects. Patients with dise

SUBMITTER: Cordon B 

PROVIDER: S-EPMC7723290 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature