The Drosophila amyloid precursor protein homologue mediates neuronal survival and neuroglial interactions.

ABSTRACT: The amyloid precursor protein (APP) is a structurally and functionally conserved transmembrane protein whose physiological role in adult brain function and health is still unclear. Because mutations in APP cause familial Alzheimer's disease (fAD), most research focuses on this aspect of APP biology. We investigated the physiological function of APP in the adult brain using the fruit fly Drosophila melanogaster, which harbors a single APP homologue called APP Like (APPL). Previous studies have provided evidence for the implication of APPL in neuronal wiring and axonal growth through the Wnt signaling pathway during development. However, like APP, APPL continues to be expressed in all neurons of the adult brain where its functions and their molecular and cellular underpinnings are unknown. W

SUBMITTER: Kessissoglou IA 

PROVIDER: S-EPMC7723294 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature