Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis.

ABSTRACT: Using a covalent chemical probe and X-ray crystallography coupled to nuclear magnetic resonance data, we elucidated the dynamic molecular basis of protein recognition between the carrier protein and adenylation domain in pyoluteorin biosynthesis. These findings reveal a unique binding mode, which contrasts previously solved carrier protein and partner protein interfaces.

SUBMITTER: Corpuz JC 

PROVIDER: S-EPMC7723355 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature