Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis.
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ABSTRACT:
SUBMITTER: Corpuz JC
PROVIDER: S-EPMC7723355 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis.
Corpuz Joshua C JC Podust Larissa M LM Davis Tony D TD Jaremko Matt J MJ Burkart Michael D MD
RSC chemical biology 20200324 1
Using a covalent chemical probe and X-ray crystallography coupled to nuclear magnetic resonance data, we elucidated the dynamic molecular basis of protein recognition between the carrier protein and adenylation domain in pyoluteorin biosynthesis. These findings reveal a unique binding mode, which contrasts previously solved carrier protein and partner protein interfaces. ...[more]
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