Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis.

ABSTRACT:

Background and aims

Circular RNA (circRNA) demonstrates potential biological application in various solid tumors. We intended to evaluate the diagnostic, prognostic, and clinicopathological value of circRNA for esophageal cancer (EC).

Methods

We screened relative studies from Pubmed, Embase, Web of Science, and Cochrane Library. The diagnostic role of circRNAs was testified by pooled sensitivity and specificity. Pooled odds ratio (OR) and pooled hazard ratio (HR) were computed to appraise the clinicopathological and prognostic value, respectively.

Results

There were total 15 articles suitable with our included criteria, in which 7 for diagnosis, 8 for prognosis, and 9 for clinicopathological features. The pooled sensitivity and specificity were 0.77 and 0.80, respecti

SUBMITTER: Lin H 

PROVIDER: S-EPMC7723476 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature