Development of a prognostic signature for bladder cancer based on immune-related genes.

ABSTRACT:

Background

Although the prognosis of patients with bladder cancer (BC) has improved significantly with the use of multimodal therapy, reliable prognostic biomarkers are still urgently needed due to the heterogeneity of tumors. Our aim was to develop an individualized immune-related gene pair (IRGP) signature that could precisely predict prognosis in BC patients.

Methods

Gene expression profiles and corresponding clinical information were collected from eight microarray data sets and one RNA-Seq data set.

Results

Among 1,811 immune genes, a 30-IRGP signature consisting of 52 unique genes was generated in the training cohort, which significantly stratified patients into low- and high-risk groups in terms of overall survival. In the testing and validation cohorts, the IR

SUBMITTER: Shi YR 

PROVIDER: S-EPMC7723522 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature