Diagnostic roles of urinary kidney microvesicles in diabetic nephropathy.

ABSTRACT:

Background

The pathology of diabetic nephropathy (DN) broadly involves the injury of glomeruli, tubulointerstitium and endothelium. Cells from these compartments can release increased numbers of microvesicles (MVs) into urine when stressed or damaged. Currently whether urinary MVs from these three parts can help diagnose DN and reflect pathological features remain unclear.

Methods

Forty-nine patients with histologically proven DN and 29 proteinuric controls with membranous nephropathy or minimal change disease were enrolled. Urinary podocyte, proximal tubular and endothelial cell-derived MVs were quantified by flow cytometry. Renal glomerular, tubulointerstitial and vascular lesions were semi-quantitatively scored and their relevance to urinary MVs were analyzed.

Results<

SUBMITTER: Cai FH 

PROVIDER: S-EPMC7723537 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature