KIF23 enhances cell proliferation in pancreatic ductal adenocarcinoma and is a potent therapeutic target.

ABSTRACT:

Background

In recent research, high expression of kinesin family member 23 (KIF23), one of the kinesin motor proteins involved in the regulation of cytokinesis, has been shown to be related to poor prognosis in glioma and paclitaxel-resistant gastric cancer, as a results of the enhancement of proliferation, migration, and invasion. In this study, we analyzed the role of KIF23 in the progression of pancreatic ductal adenocarcinoma.

Methods

A bioinformatic method was used to analyze the KIF23 mRNA level in pancreatic tumor tissues compared with normal pancreatic tissues and to analyze the connection between high KIF23 expression and prognosis. We examined the expression of KIF23 using immunohistochemistry and analyzed the connection between the expression of KIF23 and clinicop

SUBMITTER: Gao CT 

PROVIDER: S-EPMC7723550 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature