Multi-omics analysis reveals the genetics and immune landscape of dexamethasone responsive genes in cancer microenvironment.

ABSTRACT:

Background

Glucocorticoids, such as dexamethasone, are widely used for prevent vomiting and allergic reactions associated with cancer immunotherapy and chemotherapy. Although such use is reported to reduce the immunotherapy's efficacy, nevertheless, how dexamethasone associates with specific immune cells, particularly inside the tumor microenvironment, still remains unclear.

Methods

We integrate multi-omics data, including transcriptome, mutation, copy number variation (CNV), and methylation, to explore the dexamethasone responsive genes.

Results

We surprisingly found that dexamethasone responsive genes are transcriptionally down-regulated in general, where heterozygous deletion underlie such dysregulation. We further perform the pathway analysis and demonstrate that

SUBMITTER: Shen Y 

PROVIDER: S-EPMC7723561 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature