Protective effect of selegiline on cigarette smoke-induced oxidative stress and inflammation in rat lungs in vivo.

ABSTRACT:

Background

Cigarette smoke (CS)-induced build-up of oxidative stress is the leading cause of chronic obstructive pulmonary disease (COPD). Monoamine oxidases (MAOs) are novel sources of reactive oxygen species (ROS) due to the production of hydrogen peroxide (H₂O₂). However, it remains unclear whether MAO signaling is involved in CS-induced oxidative stress in vivo. This study aimed at investigating the impact of selegiline, a selective MAO-B inhibitor, on CS-induced lung oxidative stress and inflammation in vivo and its underlying mechanism.

Methods

Sprague Dawley rats were randomly divided into four groups: saline plus sham air (Saline/air), saline plus cigarette smoke (Saline/CS), selegiline plus sham air (Slg/air) and selegiline plus c

SUBMITTER: Cui Y 

PROVIDER: S-EPMC7723576 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature