Atractyloside targets cancer-associated fibroblasts and inhibits the metastasis of colon cancer.

ABSTRACT:

Background

Several evidences have proved that cancer-associated fibroblasts (CAFs) play a crucial role in tumor progression. In fact, CAFs form a major component of tumor microenvironment (TME). Therefore, the development and metastasis of tumors can be effectively inhibited by small molecular compounds that target CAFs.

Methods

In this study, we mainly analyzed the expression profile of colon cancer (CC). We determined the intensity of CAFs in CC tissues by using the immune cell infiltration score. Gene enrichment analysis and the screening of differentially expressed genes were performed on the basis of the intensity of CAFs in CC tissues. We screened the small molecular compounds that were converted from differentially expressed genes. The results indicated that atractylo

SUBMITTER: Qi L 

PROVIDER: S-EPMC7723590 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature