Degree of blood pressure control and the risk of new-onset hyperuricemia in treated hypertensive patients.

ABSTRACT:

Background

The relationship between blood pressure (BP) control and the risk of new-onset hyperuricemia remains uncertain. We aimed to examine the association between degree of time-averaged on-treatment BP control and new-onset hyperuricemia in general hypertensive patients.

Methods

A total of 10,617 hypertensive patients with normal uric acid (UA) concentrations (<357 µmol/L) at baseline were included from the UA Sub-study of the China Stroke Primary Prevention Trial (CSPPT). Participants were randomized to receive a double-blind daily treatment of enalapril 10 mg and folic acid 0.8 mg or enalapril 10 mg alone. BP measurements were taken every three months after randomization. The primary outcome was new-onset hyperuricemia, defined as a UA concentration ≥417 µmol/L in men

SUBMITTER: Li Q 

PROVIDER: S-EPMC7723605 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature