RSPO3 is a marker candidate for predicting tumor aggressiveness in ovarian cancer.

ABSTRACT:

Background

Ovarian cancer, a highly aggressive and heterogeneous gynecological malignancy that has long been difficult for physicians to identify and treat, requires more effective and precise molecular targets. R-spondin 3 (RSPO3) is a secreted protein that plays a tumorigenic role in several human cancers. However, the functional contribution and prognostic role of RSPO3 in ovarian cancer remain unclear.

Methods

RSPO3 expression in ovarian cancer tissues was assessed using western blotting, quantitative real-time polymerase chain reaction (qRT-PCR), and immunohistochemistry, and its relationships to clinicopathological parameters were investigated using the data of 179 ovarian cancer patients. RSPO3's biological function was evaluated using Cell Counting Kit-8, colony form

SUBMITTER: Gu H 

PROVIDER: S-EPMC7723610 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature