The role of ferroptosis regulators in the prognosis, immune activity and gemcitabine resistance of pancreatic cancer.

ABSTRACT:

Background

Ferroptosis is a novel form of regulated cell death that can inhibit the progression of chemotherapy-resistant tumors. However, the types of cancer most susceptible to ferroptosis induction and the role of ferroptosis regulators in cancers, especially pancreatic cancer, remain unclear.

Methods

RNA sequencing data of 31 cancers were collected from The Cancer Genome Atlas (TCGA) and The Genotype-Tissue Expression (GTEx). A nomogram integrating patients' clinical information and risk scores based on the expression levels of ferroptosis regulators was depicted. Correlations among the activity levels of 29 immunity-associated gene sets, immune scores, infiltrating immune cells and key ferroptosis regulators were assessed.

Results

We performed a pan-cancer analys

SUBMITTER: Tang R 

PROVIDER: S-EPMC7723621 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature