NcDRMarker: a computational method for identifying non-coding RNA signatures of drug resistance based on heterogeneous network.

ABSTRACT:

Background

Drug resistance is the primary cause of failure in the treatment of cancer. Identifying signatures of chemoresistance will help to overcome this problem. Current drug resistance studies focus on protein-coding genes and ignore non-coding RNAs (ncRNAs), rendering it a challenging task to systematically identify ncRNAs involved in drug resistance.

Methods

In this study, protein-protein, miRNA-target gene, miRNA-lncRNA interactions were integrated to construct a mRNA-miRNA-lncRNA network. Then, the random walk with restart (RWR) method was extended to the network for identifying ncRNA signatures of drug resistance. The leave-one-out cross validation (LOOCV) and receiver operating characteristic curve (ROC) were used to estimate the performance of ncDRMarker. Wilcoxon

SUBMITTER: Yang H 

PROVIDER: S-EPMC7723624 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature