Weighted gene co-expression network analysis identifies FCER1G as a key gene associated with diabetic kidney disease.

ABSTRACT:

Background

Diabetic kidney disease (DKD) is the primary cause of end-stage renal disease. However, the pathogenesis of DKD remains unclarified, and there is an urgent need for improved treatments. Recently, many crucial genes closely linked to the molecular mechanism underlying various diseases were discovered using weighted gene co-expression network analysis.

Methods

We used a gene expression omnibus series dataset GSE104948 with 12 renal glomerular DKD tissue samples and 18 control samples obtained from the gene expression omnibus database and performed weighted gene co-expression network analysis. After obtaining the trait-related modules, gene ontology and Kyoto encyclopedia of genes and genomes enrichment analyses of the modules were conducted and the key gene associat

SUBMITTER: Liu S 

PROVIDER: S-EPMC7723642 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature