Sphincter of Oddi laxity alters bile duct microbiota and contributes to the recurrence of choledocholithiasis.

ABSTRACT:

Background

Choledocholithiasis is closely associated with bacterial infection and inflammation in the bile duct. Our previous studies showed that sphincter of Oddi laxity (SOL) significantly altered the bile microbiota and might contribute to the recurrence of biliary stones. However, the direct association among SOL, the bile microbiota, and choledocholithiasis recurrence is unclear.

Methods

We prospectively recruited 202 patients with choledocholithiasis, and obtained bile samples from the common bile duct. We performed 16S ribosomal RNA gene analysis to characterize the bile microbiota and analyzed the risk factors for choledocholithiasis.

Results

Distinct bile microbial communities were identified in patients with and without SOL, with a significantly larger abund

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7723656 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature