Discovery of unique African Helicobacter pylori CagA-multimerization motif in the Dominican Republic.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) colonizes the human stomach and is a major cause of peptic ulcer disease and gastric cancer. However, although the prevalence of H. pylori is high in Africa, the incidence of gastric cancer is low, and this phenomenon is called to be African enigma. The CagA protein produced by H. pylori is the most studied virulence factor. The carcinogenic potential of CagA is associated with the Glu-Pro-Ile-Tyr-Ala (EPIYA) patterns and CagA-multimerization (CM) motifs.

Aim

To better understand the EPIYA patterns and CM motifs of the cagA gene.

Methods

Gastric mucosal biopsy specimens were obtained from 258 patients with dyspepsia living in the Dominican Republic, from which 120 H. pylori strains we

SUBMITTER: Ono T 

PROVIDER: S-EPMC7723664 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature