Ontology highlight
ABSTRACT:
SUBMITTER: Scheepers C
PROVIDER: S-EPMC7723817 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Cell reports 20201101 8
Neutralizing antibodies (nAbs) to highly variable viral pathogens show remarkable diversification during infection, resulting in an "arms race" between virus and host. Studies of nAb lineages have shown how somatic hypermutation (SHM) in immunoglobulin (Ig)-variable regions enables maturing antibodies to neutralize emerging viral escape variants. However, the Ig-constant region (which determines isotype) can also influence epitope recognition. Here, we use longitudinal deep sequencing of an HIV- ...[more]